Liverpool HEP Interactions

No Interaction Expected

Sofosbuvir

Ecstasy (MDMA)

Summary:

Coadministration has not been studied but based on metabolism and clearance a clinically significant interaction is unlikely as ecstasy is metabolised mainly by CYP2D6 which is not affected by sofosbuvir. Sofosbuvir is a prodrug and formation of its active metabolite is unlikely to be affected by comedications.

Description:

(See Summary)

No Interaction Expected

Sofosbuvir

Orphenadrine

Summary:

Coadministration has not been studied, but based on metabolism and clearance a clinically significant pharmacokinetic interaction is unlikely. Sofosbuvir is a prodrug and formation of its active metabolite is unlikely to be affected by comedications.

Description:

(See Summary)

No Interaction Expected

Sofosbuvir

Molly (Ecstasy, MDMA)

Summary:

Coadministration has not been studied but based on metabolism and clearance a clinically significant interaction is unlikely as ecstasy is metabolised mainly by CYP2D6 which is not affected by sofosbuvir. Sofosbuvir is a prodrug and formation of its active metabolite is unlikely to be affected by comedications.

Description:

(See Summary)

No Interaction Expected

Sofosbuvir

Acid (LSD, Lysergic acid diethylamide)

Summary:

Coadministration has not been studied but based on metabolism and clearance a clinically significant interaction is unlikely. LSD (lysergic acid diethylamide) is metabolized to O-H-LSD and N-desmethyl-LSD partly by CYP (unknown isoenzyme) and sofosbuvir has no effect on CYP enzymes. Sofosbuvir is a prodrug and formation of its active metabolite is unlikely to be affected by comedications.

Description:

(See Summary)

No Interaction Expected

Sofosbuvir

Special K (Ketamine)

Summary:

Coadministration has not been studied. Ketamine is metabolised via CYP mechanisms and a clinically significant interaction is unlikely as sofosbuvir does not affect CYP enzymes. Sofosbuvir is a prodrug and formation of its active metabolite is unlikely to be affected by comedications.

Description:

(See Summary)

Generate a personalised report in PDF format