Interaction Checker
Entries for the current year and the preceding year are shown here. Older entries can be found in the archive.
Interactions between sorafenib and lenvatinib and vernakalant have been upgraded from green to amber owing to new data from CredibleMeds. Vernakalant is now listed as a possible risk of QT prolongation.
Added: Tuesday 04 July 2023
Four new monoclonal antibody medications have been added to the drug interaction checker.
Added: Friday 16 June 2023
The comedication Hydroxyurea (Hydroxycarbamide) has been added to the interaction checker, in the Cancer Therapies class. An update is available for the apps and the PDFs will be updated in due course.
Added: Wednesday 14 June 2023
We have added a new Treatment Selector to the Prescribing Resources: Hormone Therapy for Gender Affirmation.
This new prescribing resource allows you to view all interactions at-a-glance between DAAs and medications commonly used for gender transition. We hope this helps our trans...
Added: Wednesday 03 May 2023
We are working our way through the list of comedications which users have submitted to us using the 'Suggest a Drug' form. We have added the following drugs to the website, app, and PDFs:
Added: Tuesday 18 April 2023
We have added umeclidinium bromide as a new comedication to the bronchodilators class. This comedication was suggested to us by users of the website. All of the PDFs have been updated.
Added: Tuesday 04 April 2023
We have added testosterone to the contraceptives and hormone replacements class. An update is due for the app, and the PDFs will be updated shortly.
Added: Monday 09 January 2023
The new DAA Formulations for Swallowing Difficulties Prescribing Resource in the Prescribing and Dosing Guidance section presents recommendations and PK data on crushing DAAs. The guidance draws upon product labels, case studies, and personal communications to formulate recommendations...
Added: Tuesday 11 October 2022
In response to the current increase in monkeypox infections seen in previously non-endemic areas, we have added brincidofovir and tecovirimat to the antivirals class.
Added: Tuesday 28 June 2022
We have updated two of our Treatment Selectors: the Antiepileptic Treatment Selector and the Recreational Drugs Treatment Selector. These give overviews of interactions with...
Added: Tuesday 14 June 2022
We have added the following three comedications to the interactive checker:
The Overview of Interaction PDFs have been updated to reflect this.
Added: Wednesday 14 July 2021
We have added lenvatinib and sorafenib to the interaction checker, completing our hepatocellular carcinoma indication. All the PDFs have been updated, and there are two new PK factsheets for the new primaries.
Added: Friday 12 February 2021
We have reviewed all our HCV interactions with antiepileptic drugs, as this is a combination we often receive queries about. A new treatment selector is now available, with more sedative drugs added to the list.
The new treatment selector can be found in the prescribing resources section.
Added: Friday 06 March 2020
Following review, we have updated the interactions of ombitasvir/paritaprevir/ritonavir +/- dasabuvir to YELLOW with buprenorphine. A new treatment selector for recreational drugs and DAAs can be found in the Prescribing Resources section.
Added: Tuesday 03 March 2020
Influenza vaccine has been added to the comedications list and overview of interactions charts. There is an update available for the app.
Added: Tuesday 11 February 2020
A couple more drugs suggested to us via the 'suggest a comed' form have been added; adalimumab, in the immunosuppressants class; and cyclophosphamide, in the cancer therapies class.
Added: Wednesday 05 February 2020
In collaboration with the Australasian Society for HIV, Viral Hepatitis and Sexual Health Medicine (ASHM) we have produced a flow chart explaining how to use our drug interaction tool. It is available to download in the
Added: Friday 20 December 2019
We have recently introduced Treatment Selectors to the Prescribing Resources section of the website.
Treatment Selectors show tables of interactions between key HCV DAAs and drugs used to treat common comorbidities or specific patient populations. They are available as a PDF file and have been design...
Added: Friday 13 April 2018
Four new comedications for the treatment of pulmonary hypertension have been added to the interaction checker. The new comedications listed are:
Added: Wednesday 03 January 2018
Three new drugs have been added to the comedication list. Metamizole can be found in the analgesic class, and fluindione and phenprocoumon can be found in the “anticoagulant, anti-platelet and fibrinolytic” class.
All versions of the charts (web, app...
Added: Monday 19 December 2016
Epclusa® (velpatasvir/sofosbuvir) has been approved by the FDA and EMA. Interactions with velpatasvir/sofosbuvir are now available on the web, app and printable versions of the interaction charts.
Added: Friday 15 July 2016
Added: Monday 26 November 2012
The printable charts have been updated to include all the recent additions to the list of comedications.
Added: Wednesday 04 April 2012
Added: Wednesday 20 October 2010