Interaction Checker

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GLP-1 mimetics/analogues review - plus semaglutide and tirzepatide added

Monday 16 October 2023

In the wake of increased interest in the GLP-1 mimetics for weight loss, we have reviewed this drug class. On re-examination of the evidence, we believe that delayed gastric emptying is unlikely to cause a clinically significant interaction with our primary drugs. Certain DAAs, however, (ledipasvir, ravidasvir, velpatasvir) are sensitive to increased gastric pH, which may occur with the decreased gastric secretions associated with GLP-1 mimetics, and these interactions are coded yellow. Finally, all interactions with sorafenib are yellow due to a class effect.

We have added the following GLP-1 mimetics to the interaction checker:

  • Semaglutide (Ozempic, Wegovy)
  • Tirzepatde (Mounjaro)
Awards and commendations
bma-foundation-for-medical-research british-medical-journal-2018 queens_aniversary_prize_2017 rcp-excellence-patient-care-awards-2017 building_better_healthcare_awards_2016