Interaction Checker

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Prescribing Resources

We have produced a series of printable materials in PDF format to aid prescribing.

Interpreting the Interaction Checker flowchart demonstrating how to use the drug interaction checker to manage drug-drug interactions.

Interaction Summary Tables provide an overview of interactions between hepatology drugs and the comedications listed in the interaction checker.

Treatment Selectors show interactions between key HCV DAAs and drugs used to treat a range of common comorbidities or specific patient populations.

Fact Sheets contain information on the pharmacokinetics, metabolism and disposition of drugs used to treat viral hepatitis and have been collated from product labels and published literature on licensed doses (unless otherwise stated). Please click on the headings below to see the full range of resources within each section.

Interpreting the Interaction Checker

Interpreting the Liverpool HEP Interactions Checker

Updated December 2019

Interaction Summary Tables

Interactions With HBV Treatment

Updated December 2022

Interactions With HCC Treatment

Updated December 2022

Interactions With HCV DAAs and Ribavirin

Updated December 2022

Interactions With HDV Treatment

Updated December 2022

Interactions With PBC Treatment

Updated December 2022

Treatment Selectors

Acid Reducing Agents

Updated July 2022

Anticoagulants & Antiplatelets

Updated July 2022

Antiepileptics

Updated November 2022

Antipsychotics/Neuroleptics

Updated July 2022

Recreational Drugs

Updated June 2022

Prescribing and Dosing Guidance

DAA Formulations for Swallowing Difficulties

Updated October 2022

HCV DAA PK Fact Sheets

Daclatasvir

Updated July 2022

Dasabuvir

Updated July 2022

Elbasvir

Updated July 2022

Glecaprevir

Updated July 2022

Grazoprevir

Updated July 2022

Ledipasvir

Updated July 2022

Ombitasvir

Updated July 2022

Paritaprevir

Updated July 2022

Pibrentasvir

Updated July 2022

Simeprevir

Updated July 2022

Sofosbuvir

Updated July 2022

Velpatasvir

Updated July 2022

Voxilaprevir

Updated July 2022

Hepatitis Nucleoside/tide Analogue PK Fact Sheets

Adefovir

Updated July 2022

Entecavir

Updated July 2022

Lamivudine

Updated July 2022

Ribavirin

Updated July 2022

Telbivudine

Updated July 2022

Tenofovir alafenamide

Updated July 2022

Tenofovir-DF

Updated July 2022

PBC Agents PK Fact Sheets

Obeticholic Acid

Updated July 2022

Ursodeoxycholic acid

Updated July 2022

HCC Therapies PK Fact Sheets

Lenvatinib

Updated July 2022

Pembrolizumab

Updated July 2022

Regorafenib

Updated July 2022

Sorafenib

Updated July 2022

HDV Treatments PK Fact Sheets

Bulevirtide PK Fact Sheet

Updated July 2022

External Resources

Drugs in liver cirrhosis - Health Base Foundation

Updated July 2022
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