Our interaction classification system has recently been expanded to include a new “yellow” interaction, which now sits between the original green and amber classifications. Yellow interactions are likely to be of weak intensity and as such, additional action or monitoring, or a dosage adjustment is unlikely to be required. However, healthcare professionals should be aware of the potential for an interaction as the clinical significance may vary on a patient by patient basis.
We reviewed all the amber interactions in the database and where appropriate have changed them to the new yellow classifications. Some interactions may also have been reassessed as green or red during the review process. All versions of the interaction charts (web, app and printable) have been updated to reflect this new classification and the revised interactions. Please note, it is necessary for users of the HEP iChart app to ensure that the app (as well as the data) has been updated to the latest version so that yellow interactions can be displayed.
Full details of our new interaction classification system are shown below:
- RED: These drugs should not be coadministered.
- AMBER: Potential clinically significant interaction that is likely to require additional monitoring, alteration of drug dosage or timing of administration.
- YELLOW: Potential interaction likely to be of weak intensity. Additional action/monitoring or dosage adjustment is unlikely to be required.
- GREEN: No clinically significant interaction expected.
- GREY: There are no clear data, actual or theoretical, to indicate whether an interaction will occur.